Skin biological issues in electrically enhanced transdermal delivery

作者: Philip W. Ledger

DOI: 10.1016/0169-409X(92)90027-N

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摘要: Abstract The effects of iontophoresis on biological aspects the skin have received little experimental attention, despite long history this therapeutic mode. clinical literature supports contention that, in general, is a safe procedure. Nevertheless, unwanted cutaneous can occur, ranging from erythema through small punctate lesions to painful burns. Possible mechanisms by which these arise involve transfer ions, direct effect nerves and high current density associated with appendages. Ways counteract been proposed.

参考文章(72)
Y Haruta, J M Hill, D S Rootman, Reactivation of HSV-1 in primates by transcorneal iontophoresis of adrenergic agents. Investigative Ophthalmology & Visual Science. ,vol. 31, pp. 597- 600 ,(1990)
Harold A. Abramson, Skin reactions Journal of Allergy. ,vol. 12, pp. 169- 175 ,(1941) , 10.1016/S0021-8707(41)90162-4
Fitowski Ja, Ratka P, Atypical iatrogenic presentations of molluscum contagiosum. Dermatologische Monatschrift. ,vol. 176, pp. 735- ,(1990)
S. D. Brain, J. A. Edwardson, Neuropeptides and the Skin Springer, Berlin, Heidelberg. pp. 409- 422 ,(1989) , 10.1007/978-3-642-73797-8_25
Edward Paul O'Malley, Studies on Iontophoresis ,(1953)
Richard D. Luntz, Stephen C. Jacobsen, Ion mobility limiting iontophoretic bioelectrode ,(1981)
Charles W. Jarvis, Donald A. Voita, Low voltage skin burns. Pediatrics. ,vol. 48, pp. 831- 832 ,(1971)
Joseph B. Phipps, Darrel F. Untereker, Iontophoresis apparatus and methods of producing same ,(1984)