ε-Polylysine Inhibits Pancreatic Lipase Activity and Suppresses Postprandial Hypertriacylglyceridemia in Rats

摘要: Epsilon-polylysine (epsilon-PL) has been used as a food additive in Japan for many years. In this study, it inhibited human and porcine pancreatic lipase activity substrate emulsions containing bile salts phosphatidylcholine, the concentration range of 10-1000 mg/L. At same concentrations, also destroyed emulsifying activity, suggesting that inhibitory emulsion breakdown were associated. Epsilon-PL at 1000 mg/L phosphatidylcholine alone. did not inhibit or affect substrates arabic gum polyvinyl alcohol. A comparison between epsilon-PL three types alpha-PL with differing polymerization rates was performed. The different from (44 lysine residues). maintained its after incubation trypsin, alpha-chymotrypsin pepsin, whereas not. effect on postprandial hypertriacylglyceridemia investigated rats. plasma triacylglycerol rats intragastrically administered > =15 mg/kg both fat significantly lower 2 3 h administration than alone (P < 0.05). These results strongly suggest is able to suppress dietary absorption small intestine by inhibiting activity.