Comparison of Atovaquone (566C80) with Trimethoprim-Sulfamethoxazole to Treat Pneumocystis carinii Pneumonia in Patients with AIDS
作者： Walter Hughes , Gifford Leoung , Francoise Kramer , Samuel A. Bozzette , Sharon Safrin
DOI: 10.1056/NEJM199305273282103
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摘要: Background Both trimethoprim-sulfamethoxazole and pentamidine are effective as treatments for Pneumocystis carinii pneumonia, but adverse effects frequently limit their use. Atovaquone (566C80) is a new hydroxynaphthoquinone with activity against P. carinii. Methods We conducted double-blind, multicenter study in patients the acquired immunodeficiency syndrome mild or moderately severe pneumonia. They were randomly assigned to 21 days of orally administered treatment three times daily either atovaquone (750 mg) trimethoprim (320 plus sulfamethoxazole (1600 mg). Results Of 322 histologically confirmed 160 received 162 trimethoprim-sulfamethoxazole. those who could be evaluated therapeutic efficacy, 28 138 given (20 percent) 10 146 (7 did not respond (P = 0.002). Treatment-limiting required change the...
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