Should hyperlipidaemia in dialysis patients be treated

摘要: Background. Elevated urinary albumin excretion is a common feature of essential hypertension which may be reduced by ACE-inhibition through independent reductions both systemic and intraglomerular pressure. A concurrent inhibition bradykinin breakdown involved. Methods. double-blind, randomized, 12 weeks study the effects on enalapril 20 mg In =46) vs losartan 50 daily (n=47) blood pressure, albuminuria, fasting glucose, lipids in 57 male 36 female patients with hypertension. Results. Blood pressure was similarly during treatments: 156/102 (15/5) (mean [SD] to 142/92 [14/7]) mmHg; losartan: 159/103 (17/6) 149/94 (21/9) mmHg, P<0.001. Urinary creatinine ratio significantly (from 1.14 ( x / + 2.48) (geometric mean (x antilog SD) 0.81 /+ 2.43) mg/mmol, P<0.01), as well 0.95 2.45) 0.73 xl 2.00) P<0.05). The effect albuminuria especially evident microalbuminuria. Fasting total cholesterol, HDL-cholesterol triglycerides were unchanged losartan, whereas minor found all enalapril. No difference observed between groups. Conclusion. Enalapril reduce equally hypertensive patients. adverse seen glucose lipid concentrations. Losartan treatment reduces at least effectively enalapril, suggesting that glomerular leakage profoundly affected angiotensin II.