Loss of SMAD4 staining in pre-operative cell blocks is associated with distant metastases following pancreaticoduodenectomy with venous resection for pancreatic cancer.

摘要: Background and Objectives Venous resection of locally advanced pancreatic cancer is associated with increased morbidity mortality; therefore identification patients most likely to benefit from this aggressive surgical approach an important goal. Loss SMAD4 staining on resected specimens has been outcomes. Few studies have evaluated the prognostic significance pre-operative cell blocks, which would be useful in clinical decision making for disease. Methods Clinical data were retrospectively all undergoing pancreaticoduodenectomy venous resection. Immunohistochemical was performed blocks subsequent post-operative resections. Results One hundred seventeen underwent Sixty had sufficient available staining. loss observed 70% resections earlier time metastatic disease. Pre-operative correlated well six times higher likelihood developing metastases. Conclusion In pilot study, preoperative showed a strong correlation postoperative predicted metastases cancer. Preoperative status may considered as one several factors when selecting en bloc J. Surg. Oncol. 2014; 110:171–175. © 2014 Wiley Periodicals, Inc.