Investigating phenotypes of asthma in elite performance athletes

摘要: There is a high prevalence of exercise induced bronchoconstriction in elite performance athletes. Sporting regulatory bodies advocate use objective tests for diagnosis, but how response to these relates airways inflammation unclear. We investigated responses standard direct and indirect challenge patterns symptomatic, international level, endurance Seventeen athletes who were all either inhaled corticosteroid naive (or had withdrawn corticosteroids 4 weeks) recruited. They underwent detailed assessment with questionnaires, exhaled nitric oxide, spirometry, methacholine, mannitol, EVH, exercise, sputum cell count urine mast mediator measurement. All significant eosinophilia (>3%) positive methacholine EVH. The % fall FEV1 post EVH the strongest correlation (% v logeos: r=0.652, p=0.005) an optimum cut point ≥25% (sens: 83.33%, spec: 90.91%). was strong between oxide (log FENO r=0.577, p=0.015), best off > 45 ppb 66.67%, 89.94%). challenges associated significantly higher PGE2 (ANOVA, r2=0.646, p<0.0001). no difference concentrations or testing modalities (ANOVA r2= 0.026, p=0.644).