A developmentally-stable pattern of premorbid schizoid-schizotypal features predicts psychotic transition from the clinical high-risk for psychosis state.

摘要: Abstract Background Despite the extensive research performed on prediction of psychosis from a Clinical High Risk for Psychosis state (CHR-P), positive predictive value CHR-P designation remains unsatisfactory and further models including additional clinical biological variables are required. Existing studies indicate that schizotypy assessed at baseline in “at-risk” individuals may be considered predictor transition to psychosis. This approach, however, is burdened with bias resulting possible overlap between current psychopathology schizotypal features. No so far have developmental perspective. Aim The aim study was identify associations long-standing, parent-reported premorbid level schizoid-schizotypal traits probability psychotic CHR-P. Methods mothers 107 diagnosed as presenting use Comprehensive Assessment At Mental States12/2006 were interviewed Scale Premorbid Schizoid-Schizotypal Traits (PSST). Results A high enduring found significantly associated (HR: 1.78, 95% CI: 1.40–2.27, p  Conclusions assessment parent-reported, present early development traits, which can easily settings, estimating an “at risk” disorder.