CELL RENEWAL, MATURATION AND DECAY IN THE GASTRO-INTESTINAL EPITHELIA OF NORMAL AND IRRADIATED ANIMALS

摘要: A method is described which yields much new information on the details of kinetics steady-state cell systems in normal and irradiated animals. It based high-resolution autoradiography following administration thymidine labeled with tritium. fraction tritium so delivered solidly anchored desoxyribonucleic acid (DNA) within a shod time, remainder transformed into products are washed out spontaneously or course making; histological preparation, Accordingly, only those cells remain have synthesized DNA at time labeling. Because short range beta rays, each individual nucleus can be identified certaily autoradiograph, With help closely spaced sacrifice series, it was possible to reconstruct accurately timing mitotic cycles study variations lengths interphases divisions. Also, subsequent movements differentiation been timed. These studles yield better understanding some radiation responses organization -of.steady-state systems. (auth)