Quantitative coronary angiography in the assessment of risk factors for luminal renarrowing

摘要: The major limitation of the long term success percutaneous transluminal coronary angioplasty (PTCA) is still restenosis and a complex process that only partially understood [1, 2]. Histologic studies arteries after dilation, obtained by either autopsy or atherectomy, have provided evidence strongly supports concept intimal hyperplasia proliferation smooth muscle cells, with abundant matrix production, medial intimai origin as underlying cause luminal narrowing [3–5]. Pharmacological agents aimed at reducing absolute amount are currently being investigated in many clinical trials. In these trials it presumed outcome related to an anatomical substrate, i.e. prevention reduction reactive angioplasty. If viewed intraluminal growth successful angioplasty, risk factors for should be this process. angiographically determined change lumen diameter follow-up reliable indicator applicable large study populations. Quantitative analysis most available method assessing arterial changes over time has demonstrated minimal between post-PTCA angiography non-ambiguous measurement describe continuous present [6–9].