Control of cyclic adenosine 3',5'-monophosphate levels by depolarizing agents in fungi.

摘要: It has been reported that diverse treatments which depolarize the plasma membrane of Neurospora crassa produce rapid increases in cyclic adenosine 3',5'-monophosphate (cyclic AMP) levels. In current study, active antibiotics, are known or putative depolarizing agents, were found to similar AMP increases, not only N. crassa, but also distantly related fungi Saccharomyces cerevisiae and Mucor racemosus. Uncouplers oxidative phosphorylation, have Neurospora, produced all three fungi. The time course response these various was fungal studies on depolarized central nervous tissue suggest may be depolarization eucaryotic cells. A model is proposed for microorganisms serves as a signal breakdown integrity. subsequent increase, turn, mediate cellular help protect from chemical mechanical threats its