Pathophysiological Role of Endothelin and Potential Therapeutic Targets for Receptor Antagonists

摘要: In the decade following discovery of endothelin (ET) by Yanagisawa and his colleagues (1), there has been a prodigious number studies on endothelin, its receptors, their potential role in physiological pathophysiological processes. There is an ever-increasing literature describing importance use ET-receptor antagonists diverse diseases (Table 1). A detailed description evidence implicating all listed as well citing relevant papers cannot be conducted within confines one chapter. We have, occasion, therefore, used review articles place multiple citations have concentrated our discussion four disease areas for which most provide brief descriptions some other reports appeared. As enter clinical development different trials are conducted, it likely that these “other diseases” take more prominent positions with regard to intervention antagonists.