Common variable hypogammaglobulinemia with T-cell nodular lymphoid interstitial pneumonitis and B-cell nodular lymphoid hyperplasia: Different lymphocyte populations with a similar response to prednisone therapy

摘要: Intestinal lymphoid hyperplasia and recurrent pulmonary infections by pyogenic bacteria are well-recognized accompaniments of common variable (late onset) hypogammaglobulinemia. A 35-yr-old woman with this illness had progressive insufficiency caused nodular interstitial pneumonitis, rather than infectious lung damage, intestinal hyperplasia. B cells were abundant in the nodules but absent immunoperoxidase staining. Pulmonary lymphocytes isolated single-cell suspension from biopsy 0.5% 82% T cells. Prednisone therapy improved function decreased nodules. Lymphocytic pneumonitis should be considered patients hypogammaglobulinemia restrictive disease.