Erythroid defects in TRα−/− mice
作者： Tulene S. Kendrick , Christine J. Payne , Michael R. Epis , Jessica R. Schneider , Peter J. Leedman
DOI: 10.1182/BLOOD-2007-07-101105
关键词:
摘要: Thyroid hormone and its cognate receptor (TR) have been implicated in the production of red blood cells. Here, we show mice deficient for TRalpha compromised fetal adult erythropoiesis. Erythroid progenitor numbers were significantly reduced TRalpha(-/-) livers, transit through final stages maturation was impeded. In addition, immortalized erythroblasts displayed increased apoptosis capacity proliferation differentiation. Adult had lower hematocrit levels, elevated glucocorticoid an altered stress erythropoiesis response to hemolytic anemia. Most animals contained markedly their spleens. Strikingly, 20% failed elicit a recovered very poorly from We conclude that underlying erythroid defect exists mice, demon-strating importance compartment.
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sci-hub.se 参考文章(25)
Henry G. Fein, Richard S. Rivlin, Anemia in Thyroid Diseases Medical Clinics of North America. ,vol. 59, pp. 1133- 1145 ,(1975) , 10.1016/S0025-7125(16)31963-0
D Hentzen, A Renucci, D le Guellec, M Benchaibi, P Jurdic, O Gandrillon, J Samarut, The chicken c-erbA proto-oncogene is preferentially expressed in erythrocytic cells during late stages of differentiation. Molecular and Cellular Biology. ,vol. 7, pp. 2416- 2424 ,(1987) , 10.1128/MCB.7.7.2416
Bruce A. Witthuhn, Frederick W. Quelle, Olli Silvennoinen, Taolin Yi, Bo Tang, Osamu Miura, James N. Ihle, JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin Cell. ,vol. 74, pp. 227- 236 ,(1993) , 10.1016/0092-8674(93)90414-L
Evan Ingley, David J McCarthy, Jessica R Pore, Mohinda K Sarna, Aini S Adenan, Michael J Wright, Wendy Erber, Peta A Tilbrook, S Peter Klinken, Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis. Oncogene. ,vol. 24, pp. 336- 343 ,(2005) , 10.1038/SJ.ONC.1208199
Elise Coghill, Sarah Eccleston, Vanessa Fox, Loretta Cerruti, Clark Brown, John Cunningham, Stephen Jane, Andrew Perkins, Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice Blood. ,vol. 97, pp. 1861- 1868 ,(2001) , 10.1182/BLOOD.V97.6.1861
Jan Sap, Alberto Muñoz, Klaus Damm, Yves Goldberg, Jacques Ghysdael, Achim Leutz, Hartmut Beug, Björn Vennström, The c-erb-A protein is a high-affinity receptor for thyroid hormone Nature. ,vol. 324, pp. 635- 640 ,(1986) , 10.1038/324635A0
Karine Gauthier, Olivier Chassande, Michela Plateroti, Jean‐Paul Roux, Claude Legrand, Bertrand Pain, Bernard Rousset, Roy Weiss, Jacqueline Trouillas, Jacques Samarut, Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development The EMBO Journal. ,vol. 18, pp. 623- 631 ,(1999) , 10.1093/EMBOJ/18.3.623
Evan Parganas, Demin Wang, Dimitrios Stravopodis, David J Topham, Jean-Christophe Marine, Stephan Teglund, Elio F Vanin, Sara Bodner, Oscar R Colamonici, Jan M van Deursen, Gerard Grosveld, James N Ihle, Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors Cell. ,vol. 93, pp. 385- 395 ,(1998) , 10.1016/S0092-8674(00)81167-8
A. Bauer, F. Tronche, O. Wessely, C. Kellendonk, H. M. Reichardt, P. Steinlein, G. Schutz, H. Beug, The glucocorticoid receptor is required for stress erythropoiesis Genes & Development. ,vol. 13, pp. 2996- 3002 ,(1999) , 10.1101/GAD.13.22.2996
Merav Socolovsky, Amy E.J Fallon, Stream Wang, Carlo Brugnara, Harvey F Lodish, Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice: A Direct Role for Stat5 in Bcl-XL Induction Cell. ,vol. 98, pp. 181- 191 ,(1999) , 10.1016/S0092-8674(00)81013-2