Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia.
作者： Jeffrey D. Laskin , Debra L. Laskin , Marion A. Gordon , Nosheen Ahmad , Li C. Chen
关键词:
摘要: Eicosanoids generated via cyclooxygenase-2 (COX-2) and nitric oxide produced from inducible synthase (NOSII) have been implicated in endotoxin-induced tissue injury. In the present studies, we characterized COX-2 NOSII activity rat hepatic macrophages their interaction during acute endotoxemia. Kupffer cells control animals were found to constitutively express mRNA protein. Whereas treatment of with lipopolysaccharide (LPS) and/or interferon-gamma (IFN-gamma) had no major effect on COX-2, expression increased. Induction endotoxemia resulted a rapid transient increase constitutive prostaglandin E2 (PGE2) production by liver as well release. Cells endotoxin-treated rats also sensitized generate more increased response LPS IFN-gamma. Inhibition aminoguanidine reduced protein PGE2 activated endotoxemic, but not animals. contrast, SC236, specific inhibitor, or levels macrophages, even after endotoxin administration. These data suggest that activation may be important pathophysiological endotoxin. Moreover, is involved regulating
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