Once daily timolol in the prophylaxis of angina pectoris

摘要: Abstract The clinical efficacy of timolol given once and twice daily was compared in the management angina pectoris. Following a 2-week entry period, 16 normotensive male subjects with stable proven myocardial ischaemia received 10 mg daily, or 20 every morning for 1 month followed by on crossover therapy. All were exercised separate days random order hr after administration mg, 13 25 mg. In spite significant differences maximum heart rates, rate pressure products lateral ST segment depression between regimes, maximal walking times not significantly different ( P > 0.10) attack rates trinitrin consumption similar 0.45; 0.05). This evidence suggests that is as effective dosage taken half dose symptom