Comparative metabolism of benzo[a]pyrene and drugs in human liver

摘要: The oxidative metabolism of antipyrine, hexobarbital, coumarin, zoxazolamine, 7-ethoxycoumarin, and the chemical carcinogen benzo[a]pyrene (BP) was studied in 32 adult human livers obtained at autopsy. When enzyme activity for one substrate plotted against a second each livers, statistically significant correlations were found between rates BP other five drug substrates. degree correlation dependent upon pair that studied. Highly statistical (p less than 0.001) monooxygenase activities among different observed with antipyrine (r = 0.85), zoxazolamine 0.82), hexobarbital 0.79), 7-ethoxycoumarin 0.75), coumarin ( r= 0.72), 0.71), 0.69), 0.64), 0.61), 0.57). Less 0.35; p 0.05). It is not known whether relationships several substrates described here autopsy would also occur fresh livers. lack perfect any pairs suggests presence liver multiple systems studied, as well heterogeneity their distribution examined. approach present report may have significance study comparative drugs, carcinogens, environmental pollutants by tissues help us find predictor drugs will be useful evaluating drug- carcinogen-metabolizing capacity individuals population.