Protein Thiol Redox Signaling in Monocytes and Macrophages.
作者： John D. Short , Kevin Downs , Sina Tavakoli , Reto Asmis
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摘要: Abstract Significance: Monocyte and macrophage dysfunction plays a critical role in wide range of inflammatory disease processes, including obesity, impaired wound healing diabetic complications, atherosclerosis. Emerging evidence suggests that the earliest events monocyte or dysregulation include elevated reactive oxygen species production, thiol modifications, disruption redox-sensitive signaling pathways. This review focuses on current state research redox monocytes macrophages, (i) molecular mechanisms by which reversible protein-S-glutathionylation occurs, (ii) identification bona fide S-glutathionylated proteins occur under physiological conditions, (iii) how disruptions affect functions contribute to Recent Advances: advances biochemistry biology as well proteomic techniques have led many...
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