Liposomes incorporating cyclodextrin-drug inclusion complexes: Current state of knowledge.

摘要: Cyclodextrins (CDs) are cyclic oligosaccharides, consisting of glucopyranose units, which able to form host-guest inclusion complexes with lipophilic molecules. The ability CD increase drug solubility may be used entrapment in the aqueous compartment liposomes and can protect CD/drug until release. Liposomes phospholipid vesicles composed lipid bilayers enclosing one or more compartments. They have been widely as safe effective carriers for both hydrophilic drugs. However, drugs incorporated membrane rapidly released, limits effectiveness this delivery system. coupling systems by encapsulating complex into is proposed circumvent drawbacks each separate Here, we review literature regarding encapsulation conventional, deformable double loaded liposomes. highlights characteristics these presents advantages disadvantages one.