Genetic Aspects of Muscular Strength and Size

摘要: This chapter reviews common genetic variants (single nucleotide polymorphisms; SNPs) that reportedly influence baseline and resistance training induced changes in skeletal muscle size strength. Genetic associated with strength have been found a structural gene (alpha-actinin 3), growth factor genes (e.g., insulin-like 1 myostatin), inflammatory interleukin 6 tumor necrosis alpha). The biological basis for each of these three categories is discussed SNP association studies are highlighted. In most cases, single account low percentages trait variability on their own few interactions between multiple variations investigated to date. Future would benefit from emerging high throughput genotyping methods enable comparisons across genes, which can enhance identification gene/loci associations. Potential practical applications exercise/muscle genomics include the ability identify individuals increased athletic performance, optimization rehabilitation strategies via individually tailored programs, enhanced musculoskeletal health over lifespan through development pathway targeted therapeutics.