Investigating the relationship between melatonin levels, melatonin system, microbiota composition and bipolar disorder psychopathology across the different phases of the disease.

摘要: Bipolar disorder (BD) is characterized by recurrent episodes of depression and mania/hypomania alternating with intervals well-being. The neurobiological underpinnings BD are still veiled although there evidence pointing to a malfunction the circadian clock system that regulated neuromodulator melatonin (MLT). Small sample size studies in patients have shown changes levels MLT associated shifts illness status. Moreover, mood stabilizers (including lithium valproic acid) influence system. Of interest, also modulates intestinal microbiota, recent work suggests an important role microbiota alterations neuropsychiatric disorders, including BD. This study designed explore whether possible patterns associations between its precursors phases modulated variants within genes encoding for elements and/or composition. We will conduct 2-year follow-up 50 during three different disease. For each phase, we perform blood withdrawal analysis related pathway 8 10 a.m. after overnight fasting, stool specimen collection composition, detailed psychometric assessment depression, mania, impulsivity cognitive abilities. recruit healthy age-matched controls whom collection, exclude presence psychiatric disorders. In this cross sectional (case–control vs. comparisons) longitudinal (24 months) study, expect clarify link system, psychopathology. identify some typical symptomatic clusters be more strictly variations personalized medicine perspective, subgroup may benefit from pharmacological therapy targeting Trial registration protocol was approved Ethics Committee University Hospital Agency Cagliari (PG/2019/6277)