Hepatitis C virus envelope proteins regulate CHOP via induction of the unfolded protein response
作者： Shiu‐Wan Chan , Philip Anthony Egan
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摘要: SPECIFIC AIMSIt is widely believed that unfolded protein response (UPR) contributes to the pathogenesis of a number human diseases. Despite growing evidence suggest induction UPR in virus infections, role viral envelope proteins diseases only just emerging. Therefore, we investigated regulation indicator CCAAT/enhancer-binding protein-homologous (CHOP) and engagement ER-associated degradation (ERAD) expression hepatitis C (HCV) E1 E2 because these target mature ER with tendency form malfolded aggregates hence may play HCV-related diseases.PRINCIPAL FINDINGS1. HCV activate CHOP promoterUsing transient transfection system HeLa cells luciferase reporter gene driven by full-length 954bp promoter, found caused significant activation promoter over tim...
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