Effect of Vitamin A and undernutrition on the Susceptibility of Rodents to a Malarial Parasite Plasmodium Berghei

摘要: The ability of vitamin A deficient rats to resist infection with P. berghei was investigated. When 10 × 6 erythrocytes bearing the parasite/100 g body weight were given protein energy undernourished rats, parasitemia developed in these animals at a faster pace than controls. high number (60% 95% ) red blood cells (RBC) carrying parasite noticeable within 7 days after infection, which time most this group died. pair-fed controls (protein-energy but supplemented A) fared perceptibly better an equivalent load infection. Control ad libitum fed littermates able restrict and neither nor death noted group. Oral supplements retinyl acetate enabled recover from subclinical dose 500 parasitized RBC early stage deficiency precipitated symptoms rate led development higher order beginning 10th day as compared pair yield glass adhering obtainable peritoneal exudates low rats. In vitro experiments further suggest decrease capacity exudate mice clear This improved by addition non sensitized control mice.