Prodrugs : challenges and rewards

摘要: A Case for Prodrugs.- Problems Addressable by Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs.- Topical Using Ophthalmic Drug Delivery.- Prodrugs and Parenteral Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics Pharmacodynamics.- Reduce Presystemic Metabolism.- Small Molecules.- Controlled Release - Macromolecular Proenzymes.- Targeting: Theoretical Computational Models.- Cancer-Small Monoclonal Antibody Conjugates Cancer Therapy.- Antibody-Directed Enzyme Therapy (ADEPT).- Liver-Targeted Brain.- Lymphatic Absorption Orally Administered Colonic Functional Group Approach Carboxylic Acids.- Alcohols Phenols.- Amines.- Amides, Imides Other NH-Acidic Compounds.- Benzamidines.- Phosphonates, Phosphinates, Phosphates.- Groups in Peptides.- Miscellaneous Groups.- Absorption, Distribution, Metabolism, Excretion (ADME) Issues.- Formulation Challenges Safety Assessment Toxicological Issues with Pivalate Adefovir Dipivoxil: An Adefovir.- Amifostine: (Ethyol(R)).- Capecitabine: 5-Flurouracil.- Cefditoren Pivoxil: Cefditoren.- Cefuroxime Axetil: Cefuroxime.- Clindamycin 2-Phosphate: Clindamycin.- Enalapril: Enalaprilat.- Famciclovir: Penciclovir.- Fosamprenavir: Amprenavir.- Fosinopril.- Fosphenytoin: Phenytoin.- Irinotecan (CPT-11), Water-soluble SN-38.-Latanoprost: Isopropylester a Prostaglandin F2a Analog.- Moexipril Hydrochloride: Moexiprilat.- Mycophenolate Mofetil.- Olmesartan Medoxomil: Olmesartan.- Omeprazole (PrilosecO ).- Oseltamivir: Bioavailable Ester Oseltamivir Carboxylate.- Parecoxib: Valdecoxib.- Tenofovir Disoproxil Fumarate: Tenofovir.- Travoprost: Potent PGF2a Valacyclovir: Acyclovir.- Valganciclovir: Ganciclovir.- Vantin: Cefpodoxime.- Ximelagatran: Double Melagatran