The hitch-hiking effect of a favourable gene.

摘要: SUMMARY When a selectively favourable gene substitution occurs in population, changes frequencies will occur at closely linked loci. In the case of neutral polymorphism, average heterozygosity be reduced to an extent which varies with distance from substituted locus. The aggregate eifect on polymorphism is estimated; populations total size 10 6 or more (and perhaps 4 more), this important than that random fixation. This may explain why natural does not vary as much one would expect consideration equilibrium between mutation and fixation different sizes. For maintained locus, process only long run if it leads complete If selective coefficients locus are small compared those shown probability approximately exp (— Nc), where c recombinant fraction N population size. It follows large can cistron without eliminating same cistron.