Hepatic stellate cells, liver innate immunity, and hepatitis C virus
作者： Yizhong Wang , Jieliang Li , Xu Wang , Min Sang , Wenzhe Ho
DOI: 10.1111/JGH.12023
关键词:
摘要: Chronic hepatitis C virus (HCV) infection can cause liver damage, ranging from mild to more severe conditions, such as fibrosis and cirrhosis. Hepatic stellate cell (HSC) activation is a key event in HCV-induced fibrosis. HSCs express several HCV coreceptors that interact with proteins, promoting fibrogenesis. In addition, have the ability engulf apoptotic bodies of hepatocytes induced by trigger profibrogenic response. Recent studies suggested may play novel role innate immunity. enhanced differentiation accumulation regulatory T cells. HSCs-activated natural killer cells could produce γ-interferon inhibits replication. Importantly, possess functional Toll-like receptor-3 retinoic acid-inducible gene I be activated their ligands (poly : C, 5′ppp-dsRNA), leading induction interferon inhibition replication hepatocytes. These new observations highlight importance immunity against HCV, which focus this review paper.
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