The effects of a selective noradrenaline reuptake inhibitor on the urethra: an in vitro and in vivo study.

摘要: Objective To identify the effects of a selective noradrenaline reuptake inhibitor (venlafaxine) on urethral perfusion pressure (UPP) in rabbits and rats, thus assess its therapeutic potential for treating stress urinary incontinence. Materials methods Strips bladder proximal urethra were prepared from female New Zealand White rabbits. Each strip was electrically stimulated contractile responses controls strips compared with those after pretreatment venlafaxine (100 µmol/L). In separate experiments using 80 adult Sprague–Dawley rats (250–300 g), changes intravesical UPP intra-arterial intra-urethral administration phenylephrine, phentolamine, fluoxetine monitored double-lumen catheters. Results Pretreatment significantly decreased contraction (P = 0.01) increased (P = 0.008). vivo, phenylephrine administered by both routes (P = 0.02); phentolamine (arterial) (P = 0.001); had no effect UPP, (both routes) P < 0.001). The not changed any animal. Conclusions Venlafaxine effectively vitro vivo; these results imply that may be useful incontinence, increasing UPP.