Transcriptional control of metabolic regulation genes by carbohydrates.

摘要: Glucose can modulate the transcription of many genes, particularly those encoding enzymes liver metabolism. The transcriptional effect glucose be indirect, being mediated in vivo by hormonal variations, especially increase insulin and decrease glucagon secretion. Whereas glucokinase gene, for example, is stimulated without aid glucose, activation most glycolytic lipogenic genes hepatocytes requires presence both insulin. role these seems mainly to stimulate synthesis, thus permit phosphorylation. In some cells which hexokinase activity constitutive, glucose-dependent same does not require and, addition, produced nonmetabolisable analog, 2-deoxyglucose. hepatocytes, on L-pyruvate kinase gene reproduced f...