FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells

摘要: Cranial irradiation is an effective treatment modality for both primary and metastatic brain tumors, yet it induces cognitive decline in a substantial number of patients. At present, there are no established methods neuroprotection. Recent investigations have revealed link between radiation-induced dysfunction the loss neural precursor cells hippocampus. Hence, identifying pharmacological agents, capable protecting this cell population, interest. FTY720 (fingolimod), FDA-approved oral drug multiple sclerosis, has been shown to promote survival differentiation progenitors, as well remyelination repair after injury. In study, we show that FTY720, used at nanomolar concentrations, increasing viability neurogenicity irradiated stem from contrast, does not provide radioprotection human breast cancer line two glioma lines. These results suggest potential therapeutic role neuroprotector during cranial irradiation. Further preclinical studies warranted evaluate possibility.