Fabrication, multi-scale characterization and in-vitro evaluation of porous hybrid bioactive glass polymer-coated scaffolds for bone tissue engineering.

作者: Adrian Chlanda , Przemysław Oberbek , Marcin Heljak , Ewa Kijeńska-Gawrońska , Tomasz Bolek

DOI: 10.1016/J.MSEC.2018.09.062

关键词:

摘要: Bioactive glass-based scaffolds are commonly used in bone tissue engineering due to their biocompatibility, mechanical strength and adequate porous structure. However, hydrophobicity brittleness limits practical application. In this study, improve nanomechanical properties of such scaffolds, pure bioactive hybrid glass two glass-polymer coated composites were fabricated. A complementary micro nanoscale characterization techniques (SEM, AFM, μCT, FTIR, compressive test, goniometer) implemented for detailed description architecture physicochemical with emphasis on nano-mechanics. The final step was in-vitro evaluation three dimensional macroporous structures. Our findings show that after polymer addition, architecture, topography surface the changed promoted favoured behaviour cells.

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