Comparison of Toxicity of Benzene Metabolite Hydroquinone in Hematopoietic Stem Cells Derived from Murine Embryonic Yolk Sac and Adult Bone Marrow
作者： Jie Zhu , Hong Wang , Shuo Yang , Liqiao Guo , Zhen Li
DOI: 10.1371/JOURNAL.PONE.0071153
关键词:
摘要: Benzene is an occupational toxicant and environmental pollutant that potentially causes hematotoxicity leukemia in exposed populations. Epidemiological studies suggest association between increased incidence of childhood benzene exposure during the early stages pregnancy. However, experimental evidence supporting lacking at present time. It believed its metabolites target hematopoietic stem cells (HSCs) to cause toxicity cancer system. In current study, we compared effects hydroquinone (HQ), a major metabolite humans animals, on mouse embryonic yolk sac (YS-HSCs) adult bone marrow (BM-HSCs). YS-HSCs BM-HSCs were isolated enriched, HQ increasing concentrations. reduced proliferation differentiation colony formation, but apoptosis both BM-HSCs. cytotoxic apoptotic more apparent reduction formation by was severe than Differences gene expression profiles observed HQ-treated Cyp4f18 induced BM-HSCs, whereas DNA-PKcs only. The results revealed differential HSCs. study established system for comparison leukemogenicity development adulthood.
harvard.edu
cdc.gov
paperity.org参考文章(49)
Hao You, Meng-meng Kong, Li-ping Wang, Xiao Xiao, Han-lin Liao, Zhuo-yue Bi, Hong Yan, Hong Wang, Chun-hong Wang, Qiang Ma, Yan-qun Liu, Yong-yi Bi, Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis Journal of Huazhong University of Science and Technology [Medical Sciences]. ,vol. 33, pp. 43- 50 ,(2013) , 10.1007/S11596-013-1069-Z
R Snyder, G Witz, B D Goldstein, The toxicology of benzene. Environmental Health Perspectives. ,vol. 100, pp. 293- 306 ,(1993) , 10.1289/EHP.93100293
K. Ikuta, I. L. Weissman, Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 1502- 1506 ,(1992) , 10.1073/PNAS.89.4.1502
G. Spangrude, S Heimfeld, I. Weissman, Purification and Characterization of Mouse Hematopoietic Stem Cells Science. ,vol. 241, pp. 58- 62 ,(1988) , 10.1126/SCIENCE.2898810
M T Smith, THE MECHANISM OF BENZENE-INDUCED LEUKEMIA : A HYPOTHESIS AND SPECULATIONS ON THE CAUSES OF LEUKEMIA Environmental Health Perspectives. ,vol. 104, pp. 1219- 1225 ,(1996) , 10.1289/EHP.961041219
Veronica C Nwosu, Grace E Kissling, Carol S Trempus, Hayden Honeycutt, John E French, Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways. Toxicology and Applied Pharmacology. ,vol. 196, pp. 37- 46 ,(2004) , 10.1016/J.TAAP.2003.11.010
Igor M. Samokhvalov, Natalia I. Samokhvalova, Shin-ichi Nishikawa, Cell tracing shows the contribution of the yolk sac to adult haematopoiesis Nature. ,vol. 446, pp. 1056- 1061 ,(2007) , 10.1038/NATURE05725
Julien Y. Bertrand, Abdelali Jalil, Michèle Klaine, Steffen Jung, Ana Cumano, Isabelle Godin, Three pathways to mature macrophages in the early mouse yolk sac Blood. ,vol. 106, pp. 3004- 3011 ,(2005) , 10.1182/BLOOD-2005-02-0461
TR Bradley, D Metcalf, THE GROWTH OF MOUSE BONE MARROW CELLS IN VITRO Immunology and Cell Biology. ,vol. 44, pp. 287- 300 ,(1966) , 10.1038/ICB.1966.28
Andrew D. Luster, Andrew M. Tager, T-cell trafficking in asthma: lipid mediators grease the way Nature Reviews Immunology. ,vol. 4, pp. 711- 724 ,(2004) , 10.1038/NRI1438