Tryptophan as a functional replacement for adp-ribose-arginine in recombinant proteins
作者： Joel Moss , Linda Stevens , Rita Bortell , Christelle Bourgeois
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摘要: A method is disclosed for producing a polypeptide with modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated tryptophan phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, arginine-to-tryptophan arginine-to-phenylalanine substitutions, where the ADP-ribosylated. another methods modifying immune response in subject.
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