STAT3 Expression in Host Myeloid Cells Controls Graft-versus-Host Disease Severity

摘要: Abstract Professional antigen-presenting cells (APCs) are important modulators of acute graft-versus-host disease (GVHD). Although dendritic (DCs) the most potent APC subset, other myeloid cells, especially macrophages (MFs) and neutrophils, recently have been shown to play a role in severity GVHD. The critical molecular mechanisms that determine functions GVHD unclear, however. Signal transducer activator transcription 3 (STAT3) is master factor plays crucial regulating immunity, but its MF biology remains unknown. To impact cell-specific expression STAT3 on GVHD, we used STAT3-deficient LysM-Cre/STAT3fl/− animals as recipients donors well-characterized experimental models We found reduced from hosts, not donors, increased inflammation, donor T cell activation, exacerbated Our data demonstrate host such MFs, dampens