Alterations in the functional anatomy of working memory in adult attention deficit hyperactivity disorder.

摘要: Objective: The authors used a functional neuroimaging study with working memory probe to investigate the pathophysiology of attention deficit hyperactivity disorder (ADHD). Their goal was compare regional cerebral blood flow (rCBF) changes related in adults and without ADHD. Method: Using [ 15 O]H2O positron emission tomography (PET) studies, compared sites neural activation six adult men diagnosed ADHD healthy who were matched age general intelligence. Results: Task-related rCBF more prominent frontal temporal regions, but widespread primarily located occipital regions. Conclusions: These data suggest use compensatory mental strategies by subjects response disrupted ability inhibit nonrelevant stimuli internalized speech guide behavior. (Am J Psychiatry 2000; 157:278–280) Attention (ADHD) is most common childhood psychiatric (DSM-IV) persists into adulthood for 30%–50% affected children. Neuropsychological studies (1) that it involves dysfunction memory. Brain imaging point abnormalities brain structure (2) function (3). Positron 18 F]fluorodeoxyglucose (e.g., reference 3) has identified alterations activity-linked metabolism traits rather than states. An alternate approach defining incorporates tasks explore cognitive deficits, such as defects present