Polo-like kinase expression in normal human endometrium during the menstrual cycle

摘要: The enzyme, polo-like kinase (PLK), is a mammalian serine/threonine involved in cell cycle regulation. A great deal of evidence regarding the role PLK has been obtained through studies cultured cells, though little known about its function or even expression vivo. endometrium undergoes rapid proliferation and differentiation under ovarian steroid hormone control during 28-day cycle. Thus, normal provides an excellent model which to study dependency expression. In present study, we examined features 20 samples human menstrual Ki-67 proliferating nuclear antigen (PCNA) were also as markers proliferation. Immunohistochemical showed that staining was detected basement membrane many endometrial glands, stromal some endothelial cells. number PLK-positive gland cells significantly higher late proliferative phase (19.16% 4.98%) early secretory (19.28% 4.99%) than (2.60% 2.33%) (5.76% 2.16%) (P<0.0001). seemed be correlated with PCNA glands particularly phase, reflecting cellular Nevertheless, at point decreased strongly expressed. This finding suggests may have post-mitotic functions certain specialized types. Although highest observed phases, drastically phase. These findings, taken together, indicate fluctuates over course cycle, suggesting turn associated hormone-dependent