Microwave assisted synthesize of new some benzimidazole derivatives and determination of protonation constant of these compounds in non-aqueous media
作者： Emre Mentese , Fatih Islamoglu , Esra Bal , Bahittin Kahveci
DOI: 10.5155/EURJCHEM.4.1.25-28.729
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摘要: A series of 2-substituted benzimidazole derivatives have been synthesized via microwave mediated process. Different were titrated with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, N , -dimethylformamide,tert-butyl alcohol and acetonitrile), using potentiometric method. The half neutralization potential values the corresponding pKa determined for all cases.
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sci-hub.se 参考文章(25)
Kosuke Izutsu, Acid-Base Dissociation Constants in Dipolar Aprotic Solvents ,(1991)
H. H. Takimoto, G. C. Denault, S. Hotta, The thermal decomposition of 3-azido-4-benzylideneamino-s-triazoles Journal of Heterocyclic Chemistry. ,vol. 3, pp. 119- 123 ,(1966) , 10.1002/JHET.5570030201
Bahittin Kahveci, Aykut A. Ikizler, A Convenient Synthesis of Some 4-(Alkylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones Turkish Journal of Chemistry. ,vol. 24, pp. 343- 351 ,(2000)
René Milcent, Catherine Redeuilh, Synthèse d'amino-4 aryl-3 triazol-1,2,4 ones-5 Journal of Heterocyclic Chemistry. ,vol. 16, pp. 403- 407 ,(1979) , 10.1002/JHET.5570160245
Fitnat Köseoglu, Esma Kiliç, Alev Dogan, Studies on the Protonation Constants and Solvation of α-Amino Acids in Dioxan–Water Mixtures Analytical Biochemistry. ,vol. 277, pp. 243- 246 ,(2000) , 10.1006/ABIO.1999.4371
David L. Hughes, James J. Bergan, Edward J. J. Grabowski, Amino acid chemistry in dipolar aprotic solvents: dissociation constants and ambident reactivity Journal of Organic Chemistry. ,vol. 51, pp. 2579- 2585 ,(1986) , 10.1021/JO00363A033
Ayse E. Puetuen, Goezen Bereket, Esra Keskin, Potentiometric Titrations of Some 2-Substituted 5-Nitrobenzimidazole Derivatives in Nonaqueous Solvent Journal of Chemical & Engineering Data. ,vol. 40, pp. 221- 224 ,(1995) , 10.1021/JE00017A046
Peter Köhler, The biochemical basis of anthelmintic action and resistance. International Journal for Parasitology. ,vol. 31, pp. 336- 345 ,(2001) , 10.1016/S0020-7519(01)00131-X
Emmanuelle Lipka, Marcia Folly-Klan, Julie Charton, Marie-Pierre Vaccher, Jean-Paul Bonte, Claude Vaccher, Determination of pKa values of benzimidazole derivatives from mobility obtained by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 53, pp. 1267- 1271 ,(2010) , 10.1016/J.JPBA.2010.07.023
Emre Menteşe, Hakan Bektaş, Serdar Ülker, Olcay Bekircan, Bahittin Kahveci, Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity. Journal of Enzyme Inhibition and Medicinal Chemistry. ,vol. 29, pp. 64- 68 ,(2014) , 10.3109/14756366.2012.753880