Solubilsasi Parasetamol Dengan Ryoto® Sugar Ester dan Propilenglikol

摘要: Paracetamol was an active ingredient, which is poorly soluble in water. Absorption of or slightly water influenced by the rate dissolution. Solubilization alternative to improve drug solubility with addition surfactant. The Ryoto ® sugar ester surfactant and propylene glycol cosolvent conducted determine concentration prophylene that increase stability dosage form. without combinations at a below CMC point (Critical Micell Concentration), CMC, above points row 0.005 mg/ml, 0.006 0.007 mg/ml 10% glycol. highest achieved formula 7 combination (0.007 mg/ml) (10%) recovery percentage 99.6%, also obtained best preparation not occur color change preparations during storage room temperature place protected from direct sunlight for month. solubilization preparations.