Peroxidase secretion by lacrimal glands from juvenile F344 rats.

摘要: Secretion of peroxidase by rat lacrimal glands is generally acknowledged to be greater in juvenile rats than adults. However, this phenomenon has not been so well documented as other age-related changes have been. Therefore, we studied protein and secretion response muscarinic cholinergic alpha-adrenergic stimulation from 35- 90-day-old male F344 rats. Lacrimal tissue fragments were incubated perifusion chambers, was measured carbachol or phenylephrine. There a negative first-order correlation between total age. Dose-response curves showed that at the highest doses there small but significant change secretion. phenylephrine changed significantly with increasing The content diminished about 25% during period, decrease alone sufficient explain secretory responsiveness. elicited had both first- second-order components its age 35 90 days. for 5-week (35-41day)- 12-week (84-90-day)-old maximum reduced 50%, no apparent shift dose-response curve. In contrast phenylephrine, carbachol-dependent over 35-90-day period only component. addition, curve shifted right, while remained unchanged adult tissue, reached 10 nM carbachol, times higher required animals. These occurred puberty dependent upon testicular hormones. Further, independence are consistent presence more one pool exocytotic gland. Invest Ophthalmol Vis Sci 30:562-568,1989 Studies exocrine gland function focused, large measure, effects senescence. age-dependent changes, often associated onset puberty, also occur Examples relevant include differentiation convoluted granular tubules characteristic mouse submaxillary sublingual