Methods of diagnosing diseases caused by or associated with neurofibrillary tangles by phosphospecific antibodies recognising Tau
作者： Fred Van Leuven , Maria Pihlgren , Andrea Pfeifer , Andreas Muhs , Oskar Adolfsson
DOI:
关键词:
摘要: The present invention relates to methods and compositions for the therapeutic diagnostic use in treatment of diseases disorders which are caused by or associated with neurofibrillary tangles. In particular, antibodies, specifically recognize bind phosphorylated pathological protein tau-conformers involving said antibodies tauopathies including Alzheimer's Disease (AD).
lens.org 参考文章(97)
J.H. Kennedy, L.J. Kricka, P. Wilding, Protein-protein coupling reactions and the applications of protein conjugates Clinica Chimica Acta. ,vol. 70, pp. 1- 31 ,(1976) , 10.1016/0009-8981(76)90002-4
Heiko Braak, Eva Braak, Jürgen Bohl, Staging of Alzheimer-Related Cortical Destruction European Neurology. ,vol. 33, pp. 403- 408 ,(1993) , 10.1159/000116984
Eliezer Masliah, Edward Rockenstein, Michael Mante, Leslie Crews, Brian Spencer, Anthony Adame, Christina Patrick, Margarita Trejo, Kiren Ubhi, Troy T. Rohn, Sarah Mueller-Steiner, Peter Seubert, Robin Barbour, Lisa McConlogue, Manuel Buttini, Dora Games, Dale Schenk, Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease PLoS ONE. ,vol. 6, pp. e19338- ,(2011) , 10.1371/JOURNAL.PONE.0019338
Gloria Lee, Ramasamy Thangavel, Vandana M Sharma, Joel M Litersky, Kiran Bhaskar, Sandy M Fang, Lana H Do, Athena Andreadis, Gary Van Hoesen, Hanna Ksiezak-Reding, Phosphorylation of Tau by Fyn: Implications for Alzheimer's Disease The Journal of Neuroscience. ,vol. 24, pp. 2304- 2312 ,(2004) , 10.1523/JNEUROSCI.4162-03.2004
K. Bhaskar, G. A. Hobbs, S-H. Yen, G. Lee, Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy Neuropathology and Applied Neurobiology. ,vol. 36, pp. 462- 477 ,(2010) , 10.1111/J.1365-2990.2010.01103.X
J N Verma, M Rao, S Amselem, U Krzych, C R Alving, S J Green, N M Wassef, Adjuvant effects of liposomes containing lipid A: enhancement of liposomal antigen presentation and recruitment of macrophages. Infection and Immunity. ,vol. 60, pp. 2438- 2444 ,(1992) , 10.1128/IAI.60.6.2438-2444.1992
Thomas Vanhelmont, Tom Vandebroek, Ann De Vos, Dick Terwel, Katleen Lemaire, Jayamani Anandhakumar, Vanessa Franssens, Erwin Swinnen, Fred Van Leuven, Joris Winderickx, Serine-409 phosphorylation and oxidative damage define aggregation of human protein tau in yeast Fems Yeast Research. ,vol. 10, pp. 992- 1005 ,(2010) , 10.1111/J.1567-1364.2010.00662.X
Dick Terwel, David Muyllaert, Ilse Dewachter, Peter Borghgraef, Sophie Croes, Herman Devijver, Fred Van Leuven, Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice The American Journal of Pathology. ,vol. 172, pp. 786- 798 ,(2008) , 10.2353/AJPATH.2008.070904
Gregory A. Jicha, Charles Weaver, Eric Lane, Cintia Vianna, Yvonne Kress, Julia Rockwood, Peter Davies, cAMP-Dependent Protein Kinase Phosphorylations on Tau in Alzheimer’s Disease The Journal of Neuroscience. ,vol. 19, pp. 7486- 7494 ,(1999) , 10.1523/JNEUROSCI.19-17-07486.1999
Bernard Malfroy-Camine, John W. Kozarich, Gary F. Musso, Increasing blood-brain barrier permeability with permeabilizer peptides ,(1992)