Synthesis, spectral characterization and biological evaluation of a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
作者： Pushpan Puthiyapurayil , Boja Poojary , Chandrashekhar Chikkanna , Sunil Kumar Buridipad
DOI: 10.1016/J.EJMECH.2012.06.059
关键词:
摘要: Abstract On account of the reported anticancer activity triazolothiadiazines, we have synthesized a novel series 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]- 7H -[1,2,4]triazolo[3,4 -b ][1,3,4]thiadiazines and tested for in-vitro cytotoxicity by trypan blue exclusion MTT assay. These compounds were also evaluated their in-vivo anthelmintic activity, as well antimicrobial studies. Amongst compounds, compound 7j was most promising cytotoxic agent with IC 50 value 10.54 μM in MCF-7 cells. The 7l 7q exhibited excellent activity. 7d , 7f 7o 7p 7r showed good antibacterial whereas 7e 7k antifungal structures newly characterized IR, 1 H NMR, 13 C NMR LCMS analysis.
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