Stellenwert von Globaltests der Gerinnung zur Erfassung des Rezidivrisikos venöser Thromboembolien

摘要: Role of Global Markers Coagulation for Predicting Recurrent Venous Thromboembolism. thromboembolism is a chronic and potentially fatal disease. Eight years after the acute event, 30 % patients incur another event venous thromboembolism, 5 these die pulmonary embolism. Risk recurrence determined by number potency risk factors. Determination time-consuming costly, sometimes not feasible: many carry more than one factor, relevance some factors with regard to unknown, existence so far unknown must be considered. markers coagulation can helpful stratify according their recurrence. Patients high thrombin generation have 3 times higher those lower generation. D-Dimer levels < 250 ng/ml 60 rate levels. PROLONG first interventional trial investigate efficacy safety prolonged secondary thromboprophylaxis among stratified use global marker. Patient DDimer, in whom anticoagulation was stopped six months, had who received longer period time (10.9 vs 2.0 recurrences/100 patient years). In treatment group, major bleeding complication occurred. On basis only trial, as single parameter assess cannot recommended. assays situations which decisions on optimal duration based other parameters (clinic, risk) are difficult. Z Gefasmed 2007; 4 (4): 14–6.