Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants

摘要: Dietary fibers are associated with enhanced satiety. However, the mechanism of different dietary contributing to satiety-related gastrointestinal (GI) peptide release, especially in an obese population, is still poorly understood. Polydextrose (PDX), a water-soluble glucose polymer, has demonstrated its ability reduce energy intake at subsequent meal, but action requires further research. Also, there limited evidence on capacity regulate subjective feelings appetite. This study examines effects PDX postprandial secretion GI peptides, short chain fatty acids (SCFAs), lactic acid, and appetite ratings participants. 18 non-diabetic, participants (42.0 y, 33.6 kg/m2) consumed high-fat meal (4293 kJ, 36% from fat) or without (15 g) acute, multicenter, randomized, double-blind, placebo-controlled crossover trial. Postprandial plasma concentrations namely ghrelin, cholecystokinin (CCK), glucagon-like 1 (GLP-1), YY (PYY), as well SCFAs acid were assessed. peptide, SCFA lactate then modeled using linear mixed-effects model. The hunger, satisfaction, desire eat evaluated visual analogue scales (VAS), which analyzed incremental areas under curve (iAUC) during satiation satiety periods. We found that supplementation increased GLP-1 levels more than placebo treatment (P = 0.02). In whole group, older 40 years old significantly lower (P = 0.01) compared those aged less. There no statistically significant differences CCK, PYY responses. decreased while changes found. reduced iAUC for hunger by 40% (P = 0.03) marginally satisfaction 22.5% (P = 0.08) post-meal period. hormone after meal. also elevated plasma. Therefore, may offer additional means inter-meal improve metabolism