Properties of aspirin modified enteric polymer prepared by hot-melt mixing.

摘要: Melt mixing in batch equipment or continuous extruders is a technique that recently gained the attention of pharmaceutical industry. The present work has employed hot-melt to prepare modified enteric matrix, as delayed-release dosage form. Different concentrations aspirin (ASP) ranging from 10 -30% (w/w) were melt-mixed with plasticized methacrylic acid copolymer, Eudragit(®) L100-55 mixer for 5 min at 100 °C which above polymer's glass transition temperature and below ASP's melting point. samples cooled down room compressed thin discs. Processing ASP did not promote hydrolysis ASP. X-ray diffraction spectra obtained revealed was crystalline state. However, elevated temperatures dissolved displayed plasticizing effect by reducing (Tg) lowering viscosity polymer proportion its increasing concentration. addition altered some extent rheological behavior rubbery viscous. amount loading had no significant impact on dissolution profiles. met USP requirements API release mechanism shown be diffusion dominant.