Dose Intensification in Solid Tumor Chemotherapy

摘要: Since their introduction in the 1980’s, colony-stimulating factors (CSFs) have been widely used to prevent episodes of febrile neutropenia patients who either had following chemotherapy (secondary prophylaxis) or are at high risk for this complication (primary prophylaxis). Data from randomized controlled trials has confirmed that granulocyte factor (G-CSF) can reduce incidence and duration both settings1,2,3. This reduction associated with a decrease hospital antibiotic use. However, none these solid tumor demonstrated mortality. fact reflects low pre-existing mortality most chemotherapy-induced modern era.