Recent Developments in HMBC Studies

摘要: Since its introduction, the HMBC—Heteronuclear Multiple Bond Correlation—experiment has modernized NMR spectroscopy in small to medium molecule applications. The experiment provides information about which protons are near different carbons or another heteronucleus, but not directly bonded to. This can provide a huge amount of molecular structure, since long-range proton–carbon correlations include quaternary carbons, addition protonated carbons. Impressive examples for structure elucidation organic molecules, peptides, natural products have been published last 20 years. After short introduction into basic theory, this manuscript will give reader an overview developments and improvements HMBC experiments, ranging from pulse sequences dedicated suppressing one-bond that allow distinguishing between 2JCH 3JCH cross-peaks.