Loss of Lung Health from Young Adulthood and Cardiac Phenotypes in Middle Age.
作者： Michael J. Cuttica , Laura A. Colangelo , Sanjiv J. Shah , Joao Lima , Satoru Kishi
DOI: 10.1164/RCCM.201501-0116OC
关键词:
摘要: Rationale: Chronic lung diseases are associated with cardiovascular disease. How these associations evolve from young adulthood forward is unknown. Understanding the preclinical history of could inform prevention strategies for common heart-lung conditions.Objectives: To use Coronary Artery Risk Development in Young Adults (CARDIA) study to explore development interactions.Methods: We analyzed cardiac structural and functional measurements determined by echocardiography at Year 25 CARDIA measures pulmonary function over 20 years 3,000 participants.Measurements Main Results: Decline FVC peak was larger left ventricular mass (β = 6.05 g per SD decline; P < 0.0001) greater output (β = 0.109 L/min P = 0.001). FEV1/FVC ratio smaller atrial internal dimension (β = −0.038 cm lower (β = −0.070 p...
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