The regulation of stem cell aging by Wnt signaling.

摘要: Aging is an inevitable physiological process that leads to the dysfunction of various tissues, and these changes may contribute certain diseases, ultimately death. Recent research has discovered biological pathways promote aging. This review focuses on Wnt signaling, a highly conserved secreted signaling molecule plays essential role in development function notable factor regulates Although influences aging its effects are particularly prominent neuronal tissue skeletal muscle. In tissue, neurogenesis attenuated by downregulation with Skeletal muscle can also become weaker aging, known as sarcopenia. A cause sarcopenia myogenic-to-fibrogenic trans-differentiation satellite cells excessive upregulation resulting impaired regenerative capacity aged However, exercise very useful for preventing age-related alterations Upregulation implicated positive exercise, activation adult myogenesis mature more investigations required thoroughly understand their mechanisms variety this proposes therapy elderly, prevent negative maintain quality life.