Reproductive cycles and contraception of black lemurs (Eulemur macaco macaco) with depot medroxyprogesterone acetate during the breeding season.

作者: Cheryl S. Asa , Ingrid J. Porton , Randall Junge

DOI: 10.1002/ZOO.20136

关键词:

摘要: Contraception is a critical component of population management for lemurs, but concerns about potential deleterious effects continuous, long-term treatment with synthetic progestins such as the widely used melengestrol acetate implant led us to evaluate seasonal contraception injections depot medroxyprogesterone (Depo-Provera, Upjohn Pharmacia, Kalamazoo, MI) limit duration exposure. We compared two dosage regimens in female black lemurs using vaginal cytology an indirect measure ovarian suppression. Our results indicate that both 10 mg/kg body weight at 90-day intervals or 2.5 approximately 30-day can be effective most females, although one on 10-mg dose showed signs estrus 53 days. Darkening pelage during was primary side effect noted. A more important observation extend breeding season much 9 months, considerably longer than reported previously, which necessitates extending period contraceptive treatment. Zoo Biol 26:289-298, 2007. (c) 2007 Wiley-Liss, Inc.

参考文章(18)
Cheryl S. Asa, Ingrid J. Porton, Wildlife contraception : issues, methods, and applications Johns Hopkins University Press. ,(2005)
D. Tab Rasmussen, A comparative study of breeding seasonality and litter size in eleven taxa of captive lemurs ( Lemur and Varecia ) International Journal of Primatology. ,vol. 6, pp. 501- 517 ,(1985) , 10.1007/BF02735573
U. Möhle, M. Heistermann, A. Einspanier, J.K. Hodges, Efficacy and effects of short- and medium-term contraception in the common marmoset (Callithrix jacchus) using melengestrol acetate implants. Journal of Medical Primatology. ,vol. 28, pp. 36- 47 ,(1999) , 10.1111/J.1600-0684.1999.TB00087.X
R Sitruk-Ware, Progestins and cardiovascular risk markers. Steroids. ,vol. 65, pp. 651- 658 ,(2000) , 10.1016/S0039-128X(00)00174-4
Kamal Fahmy, Mohsen Khairy, Gehan Allam, Fikry Gobran, Mohamad Alloush, Effect of depo-medroxyprogesterone acetate on coagulation factors and serum lipids in Egyptian women. Contraception. ,vol. 44, pp. 431- 444 ,(1991) , 10.1016/0010-7824(91)90033-C
C. Labrie, L. Cusan, M. Plante, S. Lapointe, F. Labrie, Analysis of the androgenic activity of synthetic “progestins” currently used for the treatment of prostate cancer Journal of Steroid Biochemistry. ,vol. 28, pp. 379- 384 ,(1987) , 10.1016/0022-4731(87)91054-5
Rachanee Kongsayreepong, Supawat Chutivongse, P George, S Joyce, JM McCone, J Garza-Flores, V Valles de Bourges, DL de La Cruz, G Perez-Palacios, M Rosseneu, W De Keersgieter, C d'Arcangues, EM Belsey, N Carlson, P Hall, F Schlagenhaft, World Health Organization, Task Force on Long-Acting Systemic Agents for Fertility Regulation, None, A multicentre comparative study of serum lipids and apolipoproteins in long-term users of DMPA and a control group of IUD users Contraception. ,vol. 47, pp. 177- 191 ,(1993) , 10.1016/0010-7824(93)90090-T
M.H. Briggs, Maxine Briggs, Glucocorticoid properties op progestogens Steroids. ,vol. 22, pp. 555- 559 ,(1973) , 10.1016/0039-128X(73)90011-1