Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-β from induced inflammasomes.

作者: Donald B. Stierle , Andrea A. Stierle , Brianna Patacini , Kyle McIntyre , Teri Girtsman

DOI: 10.1021/NP2003066

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摘要: The Berkeley Pit, an acid mine waste lake, is a source of extremophilic microorganisms that produce interesting bioactive compounds. We have previously reported the isolation berkeleydione (1), berkeleytrione (2), berkeleyacetals, and berkeleyamides from Pit Lake fungus Penicillium rubrum. In this paper we report characterization berkeleyones A-C (4, 5, 7) as well described preaustinoid A (3) A1(6) same fungus. These compounds were evaluated inhibitors signaling enzyme caspase-1 potential interleukin 1-β production by inflammasomes in induced THP-1 cell line assays.

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