A beverage of Asiatic plantain extracts alleviated postprandial oxidative stress in overweight hyperlipidemic subjects challenged with a high-fat meal: a preliminary study

摘要: There is emerging interest in the potential of phenolic compounds Asiatic plantain (Plantago asiatica L.) to attenuate vitro and vivo oxidative stress. We hypothesized that a single administration beverage may exert protective effects against postprandial This preliminary study was designed compare ability different doses mitigate high-fat meal on oxidation lipids DNA overweight hyperlipidemic subjects. In randomized, double-blind, placebo-controlled parallel design (n = 10/group), 40 subjects were administered with either placebo or 1 3 extract beverages (low, intermediate, high dose). Blood samples obtained at fasting 60, 120, 240, 360 minutes (total 5 samples) after intervention. The data showed tendency for plasma free fatty acid levels decrease response high-dose all time points. Plasma oxidized low-density lipoprotein significantly reduced 120 (P .0251 vs placebo). A comet assay revealed damage lymphocytes decreased by .0225 no treatment differences triglyceride malondialdehyde levels. maximum suppression achieved dose (20 g extract/80 mL). These results suggest protecting DNA, an be useful enhance antioxidant.