Utility of the Cobas® Plasma Separation Card as a Sample Collection Device for Serological and Virological Diagnosis of Hepatitis C Virus Infection
作者： Francisco Rodríguez-Frías , María Buti , Paula Salmeron , Josep Quer , Joan Martínez-Camprecios
DOI: 10.3390/DIAGNOSTICS11030473
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摘要: Diagnosis and clinical management of people infected with hepatitis C virus (HCV) relies on results from a combination serological virological tests. The aim this study was to compare the performance dried plasma spots (DPS), prepared using cobas® Plasma Separation Card (PSC), serum venipuncture, for HCV diagnosis. We carried out prospective DPS paired or samples. Serum samples were analyzed by immunoassay Elecsys® Anti-HCV II (Roche). viral load genotyping tests All that had high anti-HCV antibody titers in also antibody-positive, as five eight moderate titers. Eight low negative DPS. Among 80 loads between 61.5 2.2 × 108 IU/mL, 74 RNA-positive mean difference 2.65 log10 IU/mL. detection markers infection comparable conventional specimen types. However, limits higher
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